2024-03-29T14:20:06Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/631252018-09-07T06:58:09Zcom_10261_112com_10261_1col_10261_365
DIGITAL.CSIC
author
Iglesia-Vicente, Janis de la
author
Mollinedo, Faustino
2012-12-18T11:02:39Z
2012-12-18T11:02:39Z
2010
Journal of Medicinal Chemistry 53(3): 983-993 (2010)
http://hdl.handle.net/10261/63125
10.1021/jm901373w
Several series of nonlactonic podophyllic aldehyde analogues were prepared and evaluated against several human tumor cell lines. They had different combinations of aldehyde, imine, amine, ester, and amide functions at C-9 and C-9′ of the cyclolignan skeleton. All the compounds synthesized showed cytotoxicity levels in the μM range and below. Within the new series tested, compounds having an aldehyde or imine at C-9 and an ester at C-9′ were the most potent, with GI50 values in the nM range, some of them being several times more potent against HT-29 and A-549 carcinoma than against MB-231 melanoma cells. Cell cycle studies and analysis of the microtubule-disrupting capacity have demonstrated the existence of two different mechanisms of cell death induction for compounds with closely related structures. © 2010 American Chemical Society.
eng
closedAccess
Synthesis and Biological Evaluation of New Podophyllic Aldehyde Derivatives with Cytotoxic and Apoptosis-Inducing Activities
artículo
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URL
https://digital.csic.es/bitstream/10261/63125/1/accesoRestringido.pdf
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accesoRestringido.pdf
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https://digital.csic.es/bitstream/10261/63125/5/accesoRestringido.pdf.txt
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accesoRestringido.pdf.txt