2024-03-28T23:45:28Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/614302023-01-10T11:51:58Zcom_10261_133com_10261_1com_10261_54col_10261_386col_10261_307
DIGITAL.CSIC
author
Martín-Ibáñez, R.
author
Crespo, Empar
author
Esgleas, M.
author
Urbán, Noelia
author
Wang, B.
author
Waclaw, R.
author
Georgopoulos, K.
author
Martínez, Salvador
author
Campbell, Kyra
author
Vicario-Abejón, Carlos
author
Alberch, J.
author
Chan, S.
author
Kastner, P.
author
Rubenstein, John L.
author
Canals, Josep María
2012-11-28T12:39:17Z
2012-11-28T12:39:17Z
2012
Stem Cells and Development 21: 2239- 2251 (2012)
http://hdl.handle.net/10261/61430
10.1089/scd.2011.0607
22142223
Development of the nervous system is finely regulated by consecutive expression of cell-specific transcription factors. Here we show that Helios, a member of the Ikaros transcription factor family, is expressed in ectodermal and neuroectodermal-derived tissues. During embryonic development, Helios is expressed by several brain structures including the lateral ganglionic eminence (LGE, the striatal anlage); the cingulated, insular and retrosplenial cortex; the hippocampus; and the accessory olfactory bulb. Moreover, Helios is also expressed by Purkinje neurons during postnatal cerebellar development. Within the LGE, Helios expression follows a dynamic spatio-temporal pattern starting at embryonic stages (E14.5), peaking at E18.5, and completely disappearing during postnatal development. Helios is expressed by a small population of nestin-positive neural progenitor cells located in the subventricular zone as well as by a larger population of immature neurons distributed throughout the mantle zone. In the later, Helios is preferentially expressed in the matrix compartment, where it colocalizes with Bcl11b and Foxp1, well-known markers of striatal projection neurons. In addition, we observed that Helios expression is not detected in Dlx1/2 and Gsx2 null mutants, while its expression is maintained in Ascl1 mutants. These findings allow us to introduce a new transcription factor in the cascade of events that take part of striatal development postulating the existence of at least 4 different neural progenitors in the LGE. An Ascl1-independent but Gsx2-& Dlx1/2-dependent precursor will express Helios defining a new lineage for a subset of matrix striatal neurons. © 2012, Mary Ann Liebert, Inc.
eng
openAccess
Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons
artículo
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https://digital.csic.es/bitstream/10261/61430/1/Vicario-Abejon%2c2012%2cStemCellsDevelop.pdf
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Vicario-Abejon,2012,StemCellsDevelop.pdf.txt