2024-03-28T10:42:33Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/500952017-11-24T13:51:35Zcom_10261_3284com_10261_1com_10261_39col_10261_3285col_10261_292
DIGITAL.CSIC
author
Domínguez-Frutos, Elena
author
Vendrell, Victor
author
Alvarez, Yolanda
author
Zelarayan, Laura Cecilia
author
López-Hernández, Iris
author
Ros, María A.
author
Schimmang, Thomas
2012-05-24T14:27:46Z
2012-05-24T14:27:46Z
2009
Mechanisms of Development 126(10): 873-881 (2009)
http://hdl.handle.net/10261/50095
10.1016/j.mod.2009.07.004
Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates. © 2009 Elsevier Ireland Ltd. All rights reserved.
eng
openAccess
Tissue-specific requirements for FGF8 during early inner ear development
artículo
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URL
https://digital.csic.es/bitstream/10261/50095/4/Tissue-specific.pdf
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Tissue-specific.pdf
URL
https://digital.csic.es/bitstream/10261/50095/6/Tissue-specific.pdf.txt
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Tissue-specific.pdf.txt