2024-03-19T07:05:30Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/497432018-08-29T11:39:22Zcom_10261_31891com_10261_2col_10261_31892
DIGITAL.CSIC
author
Hsieh, Chia-Chien
author
Hernández-Ledesma, Blanca
author
Lumen, Ben O. de
funder
American Institute for Cancer Research
funder
European Commission
funder
Consejo Superior de Investigaciones Científicas (España)
2012-05-16T11:37:35Z
2012-05-16T11:37:35Z
2011-03
Food Chemistry 125(2): 630-636 (2011)
0308-8146
http://hdl.handle.net/10261/49743
10.1016/j.foodchem.2010.09.051
http://dx.doi.org/10.13039/100000969http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100003339
The combination of two or more chemopreventive agents is currently being used to achieve greater inhibitory effects on breast cancer cells. Anacardic acid and lunasin are two plant-derived compounds that have been associated with anti-carcinogenic properties. These compounds show inhibitory effects on cell proliferation and inducing properties of apoptosis in human breast cancer MDA-MB-231 cell line. Both lunasin and anacardic acid exert their effects through the modulation of expression of several genes involved in cell cycle, apoptosis and signal transduction. Their combination arrests the cell cycle in S-phase and induces apoptosis at higher levels than that observed when each compound is used individually. This combination also promotes the inhibition of ERBB2, AKT1, JUN and RAF1 signalling gene expression, whose up-regulation has been reported as responsible for breast cancer cells growth and resistance to apoptosis. Our results introduce these two compounds as a promising strategy to prevent/treat breast cancer.
eng
closedAccess
Anacardic acid
Lunasin
Breast cancer cells
Cell proliferation
Apoptosis
Signal transduction genes
Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells
artículo
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URL
https://digital.csic.es/bitstream/10261/49743/3/accesoRestringido.pdf
File
MD5
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application/pdf
accesoRestringido.pdf
URL
https://digital.csic.es/bitstream/10261/49743/5/accesoRestringido.pdf.txt
File
MD5
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text/plain
accesoRestringido.pdf.txt