2024-03-28T20:25:41Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/371662016-02-17T02:08:45Zcom_10261_105com_10261_1com_10261_41col_10261_358col_10261_294
DIGITAL.CSIC
author
Reyes-Irisarri, Elisabet
author
Pérez-Torres, Silvia
author
Miró, Xavier
author
Martínez, Emili
author
Puigdomènech, Pere
author
Palacios, José M.
author
Mengod Los Arcos, Guadalupe
2011-06-27T08:18:00Z
2011-06-27T08:18:00Z
2008-01
Synapse 62(1): 74-79 (2008)
0887-4476
http://hdl.handle.net/10261/37166
10.1002/syn.20459
1098-2396
Phosphodiesterases (PDE) control intracellular cyclic adenosine monophosphate (cAMP) levels, which appear to play an important role in the regulation of inflammation. PDE4B is especially important in this process. Using in situ hybridization histochemistry we first mapped the expression sites of the four PDE4B splicing forms in rat brain. Using the systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) as an inflammation model in rats, we found an increase in PDEB2 mRNA expression in choroid plexus. The differential expression of PDE4B spliced forms and the differential regulation of PDE4B2 in an inflammatory model further supports an involvement of this splicing variant in the inflammatory response.
eng
openAccess
cAMP
Inflammation
PDE4B splicing variant
In situ hybridization
Differential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expression
artículo
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URL
https://digital.csic.es/bitstream/10261/37166/1/distribution%20of%20PDE4B.pdf
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distribution of PDE4B.pdf
URL
https://digital.csic.es/bitstream/10261/37166/4/distribution%20of%20PDE4B.pdf.txt
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MD5
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distribution of PDE4B.pdf.txt