2024-03-28T11:46:19Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/270952021-12-27T15:56:49Zcom_10261_47com_10261_8col_10261_300
DIGITAL.CSIC
author
Paz, Beatriz
author
Daranas, Antonio H.
author
Norte, Manuel
author
Riobó, Pilar
author
Franco, José M.
author
Fernández, José J.
2010-08-16T09:18:56Z
2010-08-16T09:18:56Z
2008-03
Marine Drugs 6(2): 73-102 (2008)
1660-3397
http://hdl.handle.net/10261/27095
10.3390/md20080005
18728761
Yessotoxin (YTX) is a marine polyether toxin that was first isolated in 1986 from the scallop Patinopecten yessoensis. Subsequently, it was reported that YTX is produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. YTXs have been associated with diarrhetic shellfish poisoning (DSP) because they are often simultaneously extracted with DSP toxins, and give positive results when tested in the conventional mouse bioassay for DSP toxins. However, recent evidence suggests that YTXs should be excluded from the DSP toxins group, because unlike okadaic acid (OA) and dinophyisistoxin-1 (DTX-1), YTXs do not cause either diarrhea or inhibition of protein phosphatases. In spite of the increasing number of molecular studies focused on the toxicity of YTX, the precise mechanism of action is currently unknown. Since the discovery of YTX, almost forty new analogues isolated from both mussels and dinoflagellates have been characterized by NMR or LC-MS/MS techniques. These studies indicate a wide variability in the profile and the relative abundance of YTXs in both, bivalves and dinoflagellates. This review covers current knowledge on the origin, producer organisms and vectors, chemical structures, metabolism, biosynthetic origin, toxicological properties, potential risks to human health and advances in detection methods of YTXs.
eng
openAccess
Yessotoxin (YTX)
Diarrhetic Shellfish Poisoning (DSP)
Marine polyether toxin
Protoceratium reticulatum
Lingulodinium polyedrum
Gonyaulax spinifera
Yessotoxins, a Group of Marine Polyether Toxins: an Overview
artículo
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URL
https://digital.csic.es/bitstream/10261/27095/1/md-6-073.pdf
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md-6-073.pdf
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https://digital.csic.es/bitstream/10261/27095/4/md-6-073.pdf.txt
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md-6-073.pdf.txt