2024-03-28T10:45:44Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2365762022-03-11T09:36:43Zcom_10261_11773com_10261_1col_10261_11774
DIGITAL.CSIC
author
Malo, Ana-Irene
author
Rull, Anna
author
Girona, Josefa
author
Domingo, Pere
author
Fuertes-Martín, Rocío
author
Amigó, Núria
author
Rodríguez-Borjabad, Cèlia
author
Martínez-Micaelo, Neus
author
Leal, Manuel
author
Peraire, Joaquim
author
Correig, Xavier
author
Vidal, Francesc
author
Masana, Lluis
funder
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España)
funder
Instituto de Salud Carlos III
funder
Red Española de Investigación en SIDA
funder
European Commission
funder
Agència de Gestió d'Ajuts Universitaris i de Recerca
funder
Diputación de Tarragona
funder
Talent Salut
funder
Universidad Rovira i Virgili
funder
Generalitat de Catalunya
funder
Ministerio de Economía y Competitividad (España)
2021-03-31T12:50:02Z
2021-03-31T12:50:02Z
2020-05-04
Journal of Clinical Medicine 9(5): 1344 (2020)
http://hdl.handle.net/10261/236576
10.3390/jcm9051344
http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100002809http://dx.doi.org/10.13039/501100004587http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/501100007512http://dx.doi.org/10.13039/501100003030
Plasma glycoproteins are a composite biomarker of inflammation and can be detected by 1H-NMR. The aim of this study was to prospectively appraise the clinical value of plasma glycoproteins assessed by 1H-NMR in people living with HIV (PLWH). A total of 221 patients with HIV infection were recruited and studied at baseline and at 48 and 144 weeks. Patients were distributed into two groups according to baseline CD4+ T-cell number below or above 200 cells/µL. Patients with fewer than 200 cells/µL were distributed into the responders and nonresponders according to antiretroviral therapy (ART) response at 144 weeks. Glycoprotein concentrations were determined by 1H-NMR arising from the protein bond N-acetylglucosamine and N-acetylgalactosamine signals (GlycA); and N-acetylneuraminic acid signal (GlycB) associated with the sugar–protein bond concentration and aggregation state (shapes (height/width)). Basal glycoprotein concentrations were higher in patients with < 200 CD4+ T-cell/μL (Glyc A: 1040(917.9–1199.1) vs. 950.4(845.5–1050.9), p < 0.001, and Glyc B: 521(440.3–610.3) vs. 468.6(417.9–507.0) μ mol/L, p < 0.001) being reduced by ART. The height/width (H/W) ratio was the parameter showing a better association with this clinical status. Baseline glycoproteins predict the condition of responder/nonresponder. In this study, 1H-NMR glycoproteins provide novel insights to assess inflammation status and have prognostic value in PLWH.
openAccess
HIV-1
Glycoprotein
Proton nuclear magnetic resonance (1H-NMR)
Inflammation
Immunological responders
Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study
artículo
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URL
https://digital.csic.es/bitstream/10261/236576/1/HIV_Infection.pdf
File
MD5
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2185848
application/pdf
HIV_Infection.pdf