2024-03-28T17:08:06Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2303472022-02-09T15:43:35Zcom_10261_105com_10261_1col_10261_484
DIGITAL.CSIC
author
Bardallo, Raquel G.
author
Teixeira da Silva, Rui
author
Panisello-Roselló, Arnau
author
Folch-Puy, Emma
author
Roselló-Catafau, Joan
author
Carbonell, Teresa
2021-02-22T13:28:40Z
2021-02-22T13:28:40Z
2020-04
American Journal of Transplantation 20(S3) (2020)
1600-6135
http://hdl.handle.net/10261/230347
10.1111/ajt.16171
1600-6143
Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution determines the outcome of the transplanted liver. It has been demonstrated that PEG35 is a key factor in the IGL-1 preservation solution. Therefore, a modified IGL-1 solution (with increased PEG concentration) was compared to HTK and UW preservation solutions. The aim of this communication is to investigate the effects of the oncotic agent PEG 35 on NLRP3 inflammasome activity and redox state during static preservation.
Methods: Fatty livers from male Zücker obese rats were preserved for 24 h at 4ºC in the studied solutions. After organ recovery and rinsing liver grafts with Ringer Lactate solution, liver injury was measured as AST/ALT and GLDH; redox state as GSH/GSSG, GST, GR, GPx, 4HNE; and inflammasome and precursors measured as NLRP3, HMGB1, and GRP78.
Results: Increases in the reducing redox capability of the cell are associated with decreased inflammasome activation and liver damage.
Conclusions: Data reported here show that the solution with increased content of PEG35 (Modified IGL-1) well correlated with a better protection through a significant prevention of inflammation in front of UW and HTK.
eng
openAccess
Glutathione
Inflammation
Ischemia
Liver preservation
DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions
póster de congreso
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URL
https://digital.csic.es/bitstream/10261/230347/3/Bardallo%20RG.%20DAMPs%20and%20NLRP3%20Inflammasome%20Response%20in%20Fatty%20Liver%20Grafts....pdf
File
MD5
e99908cc512a7b3d42836c855dad2bbe
9235
application/pdf
Bardallo RG. DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts....pdf