2024-03-29T05:52:14Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2291312023-01-04T20:08:58Zcom_10261_11773com_10261_1col_10261_11774
DIGITAL.CSIC
author
Rivero-Juárez, Antonio
author
Guijo-Rubio, David
author
Téllez, Francisco
author
Palacios, Rosario
author
Merino, Dolores
author
Macías Sánchez, Juan
author
Fernández, Juan Carlos
author
Gutiérrez, Pedro Antonio
author
Rivero, Antonio
author
Hervás-Martínez, César
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Agencia Estatal de Investigación (España)
funder
European Commission
funder
Fundación para la investigación biomédica de Córdoba (España)
2021-02-10T10:50:30Z
2021-02-10T10:50:30Z
2020-01-10
PLoS ONE 15(1): e0227188 (2020)
http://hdl.handle.net/10261/229131
10.1371/journal.pone.0227188
http://dx.doi.org/10.13039/501100011033http://dx.doi.org/10.13039/501100000780
31923277
Several European countries have established criteria for prioritising initiation of treatment in patients infected with the hepatitis C virus (HCV) by grouping patients according to clinical characteristics. Based on neural network techniques, our objective was to identify those factors for HIV/HCV co-infected patients (to which clinicians have given careful consideration before treatment uptake) that have not being included among the prioritisation criteria. This study was based on the Spanish HERACLES cohort (NCT02511496) (April-September 2015, 2940 patients) and involved application of different neural network models with different basis functions (product-unit, sigmoid unit and radial basis function neural networks) for automatic classification of patients for treatment. An evolutionary algorithm was used to determine the architecture and estimate the coefficients of the model. This machine learning methodology found that radial basis neural networks provided a very simple model in terms of the number of patient characteristics to be considered by the classifier (in this case, six), returning a good overall classification accuracy of 0.767 and a minimum sensitivity (for the classification of the minority class, untreated patients) of 0.550. Finally, the area under the ROC curve was 0.802, which proved to be exceptional. The parsimony of the model makes it especially attractive, using just eight connections. The independent variable “recent PWID” is compulsory due to its importance. The simplicity of the model means that it is possible to analyse the relationship between patient characteristics and the probability of belonging to the treated group.
openAccess
Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
artículo
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URL
https://digital.csic.es/bitstream/10261/229131/1/HIV-HCV_infection.pdf
File
MD5
43ffc6bada8b8f2cc4e8d68b2428cdc8
907310
application/pdf
HIV-HCV_infection.pdf