2024-03-29T06:21:26Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2170792021-12-28T16:17:38Zcom_10261_70com_10261_2col_10261_323
DIGITAL.CSIC
author
Herranz, Beatriz
author
Álvarez, M. Dolores
author
Pérez-Jiménez, Jara
funder
Ministerio de Economía y Competitividad (España)
funder
European Commission
2020-07-27T11:40:02Z
2020-07-27T11:40:02Z
2018-10-09
PLoS ONE 13(10): e0204075 (2018)
http://hdl.handle.net/10261/217079
10.1371/journal.pone.0204075
http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/501100000780
30300348
There is increasing interest in the search for accurate, repeatable and widely applicable clinical biomarkers for the early detection of cardiometabolic alterations and oxidative status. Viscosity is a promising tool in that sense, although most studies have used simple viscosimeters, providing limited information, and have not considered oxidative status. The aim of this study was to assess whether viscosity determinations were associated with cardiometabolic and oxidative status in subjects at a primary stage of cardiometabolic risk. A pilot study (n = 20) was conducted in subjects with abdominal obesity, determining urine and plasma viscosity with a rotational rheometer at different shear rates (10000–1000 s–1 in plasma and 1000–50 s–1 in urine). Simple regression showed that urine viscosity was significantly (p< 0.05) associated with markers of oxidative status, and plasma viscosity with blood glucose. Categorical Principal Component Analysis plots showed that urine viscosity measurements at different shear rates clustered in three groups (low, intermediate and high shear rates) were selectively associated with uric acid, polyphenols and antioxidant capacity respectively. Plasma viscosity did not seem to be a relevant clinical marker in subjects with abdominal obesity. Therefore, urine viscosity could potentially serve as a complimentary marker in the evaluation of oxidative status.
openAccess
Association of plasma and urine viscosity with cardiometabolic risk factors and oxidative status. A pilot study in subjects with abdominal obesity
artículo
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URL
https://digital.csic.es/bitstream/10261/217079/1/abdominal_obesity.pdf
File
MD5
c88ac425974454e6b300f76515422392
715558
application/octet-stream
abdominal_obesity.pdf