2024-03-29T00:25:39Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2122672020-05-28T01:11:18Zcom_10261_48com_10261_5col_10261_301
DIGITAL.CSIC
author
Miranda, Pedro O.
author
Padrón, José M.
author
Padrón, Juan I.
author
Villar, Jesús
author
Martín, Víctor S.
funder
Ministerio de Educación y Cultura (España)
funder
Ministerio de Ciencia y Tecnología (España)
funder
Gobierno de Canarias
2020-05-27T06:51:41Z
2020-05-27T06:51:41Z
2006-03-01
ChemMedChem 1(3): 323-329 (2006)
860-7179
http://hdl.handle.net/10261/212267
10.1002/cmdc.200500057
1860-7187
http://dx.doi.org/10.13039/501100006280
A series of functionalized tetrahydropyran and dihydropyran derivatives was synthesized by means of a Prins‐type cyclization between unsaturated alcohols and several aldehydes. An unprecedented dimer bearing two 4‐chloro‐5,6‐dihydro‐2H ‐pyran scaffolds was obtained in high yield. A panel of three representative human solid tumor cells from diverse origin was used to assess the cytotoxicity of the compounds. Overall, the results show the relevance of the chlorovinyl group in the biological activity, and 2‐alkyl‐4‐chloro‐5,6‐dihydro‐2H ‐pyrans represent interesting leads for further chemical modifications and biological studies.
eng
closedAccess
Antitumor agents
Iron(III ) chloride
Organohalogen drugs
Prins reaction
Structure–activity relationship
Prins‐Type Synthesis and SAR Study of Cytotoxic Alkyl Chloro Dihydropyrans
artículo
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URL
https://digital.csic.es/bitstream/10261/212267/1/accesoRestringido.pdf
File
MD5
20de8818c988f36360fa2258d359ea8a
16728
application/pdf
accesoRestringido.pdf