2024-03-28T23:46:39Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2078642021-12-28T15:51:54Zcom_10261_9676com_10261_8col_10261_9677
DIGITAL.CSIC
author
Secolin, Rodrigo
author
Mas-Sandoval, Alex
author
Arauna, Laura R.
author
Torres, Fábio R.
author
de Araujo, Tânia K.
author
Santos, Marilza L.
author
Rocha, Cristiane S.
author
Carvalho, Benilton S.
author
Cendes, Fernando
author
Lopes-Cendes, Iscia
author
Comas, David
funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
funder
Conselho Nacional das Fundaçôes Estaduais de Amparo à Pesquisa (Brasil)
funder
Generalitat de Catalunya
funder
Ministerio de Economía y Competitividad (España)
2020-04-16T10:45:35Z
2020-04-16T10:45:35Z
2019-09-25
Scientific Reports 9: 13900 (2019)
http://hdl.handle.net/10261/207864
10.1038/s41598-019-50362-2
http://dx.doi.org/10.13039/501100001807http://dx.doi.org/10.13039/501100002809http://dx.doi.org/10.13039/501100003329
31554886
Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events.
openAccess
Evolutionary biology
Genetics
Distribution of local ancestry and evidence of adaptation in admixed populations
artículo
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URL
https://digital.csic.es/bitstream/10261/207864/1/distribution_ancestry_evidence_adaptation_admixed.pdf
File
MD5
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application/pdf
distribution_ancestry_evidence_adaptation_admixed.pdf