2024-03-29T10:58:43Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1845532021-12-27T16:41:43Zcom_10261_25com_10261_1com_10261_11773col_10261_278col_10261_11774
DIGITAL.CSIC
author
Martín-Gutiérrez, Guillermo
author
Docobo-Pérez, Fernando
author
Rodríguez Beltrán, Jerónimo
author
Rodríguez-Martínez, José-Manuel
author
Aznar Martín, Javier
author
Pascual, Álvaro
author
Blázquez Gómez, Jesús
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Red Española de Investigación en Patología Infecciosa
funder
European Commission
funder
Junta de Andalucía
funder
Universidad de Sevilla
2019-06-21T07:33:59Z
2019-06-21T07:33:59Z
2018
Antimicrobial Agents and Chemotherapy 62: e01899-17 (2018)
0066-4804
http://hdl.handle.net/10261/184553
10.1128/AAC.01899-17
1098-6596
http://dx.doi.org/10.13039/100009042http://dx.doi.org/10.13039/501100010198http://dx.doi.org/10.13039/501100004587http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100011011
29038268
The steps by which Escherichia coli strains harboring mutations related to fosfomycin (FOS) resistance arise and spread during urinary tract infections (UTIs) are far from being understood. The aim of this study was to evaluate the effects of urine, pH, and anaerobiosis on FOS activity against a set of isogenic strains carrying the most prevalent chromosomal mutations conferring FOS resistance (ΔuhpT, ΔglpT, ΔcyaA, and ΔptsI), either singly or in combination. We also studied fosfomycin-resistant E. coli clinical isolates from patients with UTI. Our results demonstrate that urinary tract physiological conditions might have a profound impact on FOS activity against strains with chromosomal FOS resistance mutations. Specifically, acidic pH values and anaerobiosis convert most of the strains categorized as resistant to fosfomycin according to the international guidelines to a susceptible status. Therefore, urinary pH values may have practical interest in the management of UTIs. Finally, our results, together with the high fitness cost associated with FOS resistance mutations, might explain the low prevalence of fosfomycin-resistant E. coli variants in UTIs.
eng
closedAccess
Fosfomycin activity
Fosfomycin resistance
Chromosomal mutations
UTI
Escherichia coli
Urinary tract infection
Urinary Tract Conditions Affect Fosfomycin Activity against Escherichia coli Strains Harboring Chromosomal Mutations Involved in Fosfomycin Uptake
artículo
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URL
https://digital.csic.es/bitstream/10261/184553/1/accesoRestringido.pdf
File
MD5
ebc0238b6993fbe94c581f365dfc5974
60661
application/pdf
accesoRestringido.pdf