2024-03-28T10:19:10Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1805932021-12-27T15:59:08Zcom_10261_86com_10261_1col_10261_339
DIGITAL.CSIC
author
Schrenk, Dieter
author
Bignami, Margherita
author
Bodin, Laurent
author
Chipman, James Kevin
author
Del Mazo, Jesús
author
Grasl-Kraupp, Bettina
author
Hogstrand, Christer
author
Hoogenboom, Laurentius (Ron)
author
Leblanc, Jean-Charles
author
Nebbia, Carlo Stefano
author
Nielsen, Elsa
author
Ntzani, Evangelia
author
Petersen, Annette
author
Sand, Salomon
author
Vleminckx, Christiane
author
Wallace, Heather
author
Benford, Diane
author
Brimer, Leon
author
Mancini, Francesca Romana
author
Metzler, Manfred
author
Viviani, Bárbara
orcid
Del Mazo, Jesús [0000-0003-3269-3895]
2019-04-25T15:21:56Z
2019-04-25T15:21:56Z
2019-04
EFSA Journal 17(4) 5652 (2019)
1831-4732
http://hdl.handle.net/10261/180593
10.2903/j.efsa.2019.5662
32626287
In 2016, the EFSA Panel on Contaminants in the Food Chain (CONTAM) published a scientific opinion
on the acute health risks related to the presence of cyanogenic glycosides (CNGs) in raw apricot
kernels in which an acute reference dose (ARfD) of 20 lg/kg body weight (bw) was established for
cyanide (CN). In the present opinion, the CONTAM Panel concluded that this ARfD is applicable for
acute effects of CN regardless the dietary source. To account for differences in cyanide bioavailability
after ingestion of certain food items, specific factors were used. Estimated mean acute dietary
exposures to cyanide from foods containing CNGs did not exceed the ARfD in any age group. At the
95th percentile, the ARfD was exceeded up to about 2.5-fold in some surveys for children and
adolescent age groups. The main contributors to exposures were biscuits, juice or nectar and pastries
and cakes that could potentially contain CNGs. Taking into account the conservatism in the exposure
assessment and in derivation of the ARfD, it is unlikely that this estimated exceedance would result in
adverse effects. The limited data from animal and human studies do not allow the derivation of a
chronic health-based guidance value (HBGV) for cyanide, and thus, chronic risks could not be
assessed.
eng
openAccess
Cyanide
Cyanogenic glycosides
Health-based guidance values
Risk assessment
Evaluation of the health risks related to the presence of cyanogenic glycosides in foods other than raw apricot kernels
artículo
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URL
https://digital.csic.es/bitstream/10261/180593/3/j.efsa_Del%20Mazo_2019.pdf
File
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j.efsa_Del Mazo_2019.pdf