2024-03-29T02:34:47Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1804012021-12-27T16:53:42Zcom_10261_11773com_10261_1col_10261_11774
DIGITAL.CSIC
author
Navarro-Garrido, Victoria
author
Sánchez-Mejias, Elisabeth
author
Jiménez, Sebastián
author
Muñoz-Castro, Clara
author
Sánchez-Varo, Raquel
author
Dávila, José C.
author
Vizuete, Marisa
author
Gutiérrez, Antonia
author
Vitorica, Javier
funder
Instituto de Salud Carlos III
funder
European Commission
funder
Junta de Andalucía
funder
Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)
2019-04-23T11:44:13Z
2019-04-23T11:44:13Z
2018-05-11
Frontiers in Aging Neuroscience 10: 140 (2018)
http://hdl.handle.net/10261/180401
10.3389/fnagi.2018.00140
1663-4365
http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100004587http://dx.doi.org/10.13039/501100011011
29867449
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, the immune system and microglial cells (as part of the cerebral immunity) play a central role. In other degenerative processes, such as Alzheimer’s disease (AD), the role of microglia is far to be elucidated. In this “mini-review” article, we briefly highlight our recent data comparing the microglial response between amyloidogenic transgenic models, such as APP/PS1 and AD patients. Since the AD pathology could display regional heterogeneity, we focus our work at the hippocampal formation. In APP based models a prominent microglial response is triggered around amyloid-beta (Aβ) plaques. These strongly activated microglial cells could drive the AD pathology and, in consequence, could be implicated in the neurodegenerative process observed in models. On the contrary, the microglial response in human samples is, at least, partial or attenuated. This patent difference could simply reflect the lower and probably slower Aβ production observed in human hippocampal samples, in comparison with models, or could reflect the consequence of a chronic long-standing microglial activation. Beside this differential response, we also observed microglial degeneration in Braak V–VI individuals that, indeed, could compromise their normal role of surveying the brain environment and respond to the damage. This microglial degeneration, particularly relevant at the dentate gyrus, might be mediated by the accumulation of toxic soluble phospho-tau species. The consequences of this probably deficient immunological protection, observed in AD patients, are unknown.
eng
openAccess
Alzheimer disease
Microglia
APP models
Inflamation
Abeta plaques
Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
artículo
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URL
https://digital.csic.es/bitstream/10261/180401/1/fnagi-10-00140.pdf
File
MD5
0ccee26393153c2bd726b5878be158aa
2174214
application/pdf
fnagi-10-00140.pdf