2024-03-29T14:00:55Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1684142020-12-10T15:46:42Zcom_10261_112com_10261_1col_10261_365
DIGITAL.CSIC
author
Gomez-Marcos, Manuel A.
author
Martínez-Salgado, Carlos
author
González-Sarmiento, Rogelio
author
Hernández, Jesús M.
author
Sánchez-Fernández, Pedro Luis
author
Recio-Rodríguez, José I.
author
Rodriguez-Sanchez, Emiliano
author
García-Ortiz, Luis
funder
Universidad de Salamanca
funder
Instituto de Salud Carlos III
funder
Junta de Castilla y León
funder
Ministerio de Economía y Competitividad (España)
funder
European Commission
2018-08-08T07:31:26Z
2018-08-08T07:31:26Z
2016
BMJ Open 6(6): e011031 (2016)
http://hdl.handle.net/10261/168414
10.1136/bmjopen-2016-011031
http://dx.doi.org/10.13039/501100004587http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100014180
27267107
[Introduction]: The process of population ageing that is occurring in developed societies represents a major challenge for the health system. The aim of this study is to analyse factors that have an influence on early vascular ageing (EVA), estimated by carotid-femoral pulse wave velocity (cf-PWV) and Cardio Ankle Vascular Index (CAVI), and to determine differences by gender in a Spanish population. [Methods and analysis]: An observational, descriptive, cross-sectional study. [Study population]: From the population assigned to the participating healthcare centres, a cluster random sampling stratified by age and gender will be performed to obtain 500 participants aged between 35 and 75. Those who meet the inclusion criteria and give written informed consent will be included in the study. [Measurements]: Main dependent variables: cf-PWV determined using the SphygmoCor System and CAVI estimated using VASERA. Secondary dependent variables: telomere length, carotid intima-media thickness, central and peripheral augmentation index, ankle-brachial pulse wave velocity, ankle-brachial index, retinal arteriovenous index, and renal and cardiac organ damage. Independent variables: lifestyles (physical activity, adherence to the Mediterranean diet, alcohol and tobacco consumption); psychological factors (depression, anxiety and chronic stress); inflammatory factors and oxidative stress.
[Ethics and dissemination]: The study has been approved by the clinical research ethics committee of the healthcare area of Salamanca. All study participants will sign an informed consent form agreeing to participate in the study in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow the understanding of the relationship of the different influencing factors and their relative weight in the development of EVA. At least 5 publications in firstquartile scientific journals are planned. [Trial registration number]: NCT02623894; Pre-results.
eng
openAccess
Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study
artículo
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URL
https://digital.csic.es/bitstream/10261/168414/1/EVAstudy.pdf
File
MD5
29006d12470c2aa9c6729c01718f38b7
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application/pdf
EVAstudy.pdf