2024-03-28T10:21:32Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1645422020-12-13T09:17:36Zcom_10261_3284com_10261_1col_10261_3285
DIGITAL.CSIC
author
Álvarez, Pilar
author
Genre, Fernanda
author
Iglesias, Marcos
author
Augustin, Juan Jesús
author
Tamayo, Esther
author
Escolà-Gil, Joan Carles
author
Lavín, Bernardo
author
Blanco-Vaca, Francisco
author
Merino, Ramón
author
Merino, Jesús
funder
Fibrostatin
funder
Ministerio de Economía y Competitividad (España)
funder
European Commission
2018-05-08T10:59:02Z
2018-05-08T10:59:02Z
2016
Clinical and Experimental Immunology 186(3): 292-303 (2016)
http://hdl.handle.net/10261/164542
10.1111/cei.12857
http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100003329
27571306
Apolipoprotein E (ApoE) deficiency promoted an exacerbation of autoimmune arthritis in mice by inducing proinflammatory immune responses. In this study we analysed the contribution of hypercholesterolaemia and/or the absence of ApoE anti-inflammatory properties, unrelated to its function in the control of cholesterol metabolism, towards the acceleration of arthritis in these mutant animals. The induction and severity of collagen type II-induced arthritis (CIA) were compared for B10.RIII wild-type (WT), B10.RIII.ApoE, B10.RIII.ApoE and B10.RIII.low-density lipoprotein receptor (LDLR) mice with different concentrations of circulating ApoE and cholesterol. A 50–70% reduction in serum levels of ApoE was observed in heterozygous B10.RIII.ApoE mice in comparison to B10.RIII.WT, although both strains of mice exhibited similar circulating lipid profiles. This ApoE reduction was associated with an increased CIA severity that remained lower than in homozygous B10.RIII.ApoE mice. An important rise in circulating ApoE concentration was observed in hypercholesterolaemic B10.RIII.LDLR mice fed with a normal chow diet, and both parameters increased further with an atherogenic hypercholesterolaemic diet. However, the severity of CIA in B10.RIII.LDLR mice was similar to that of B10.RIII.WT controls. In conclusion, by comparing the evolution of CIA between several strains of mutant mice with different levels of serum ApoE and cholesterol, our results demonstrate that both hypercholesterolaemia and ApoE regulate the intensity of in-vivo systemic autoimmune responses.
eng
openAccess
ApoE
LDLR
Collagen type II-induced arthritis
Hypercholesterolaemia
Modulation of autoimmune arthritis severity in mice by apolipoprotein E (ApoE) and cholesterol
artículo
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URL
https://digital.csic.es/bitstream/10261/164542/1/modulationcholesterol.pdf
File
MD5
cfce9d527a8c90c976291bf8e5890540
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application/pdf
modulationcholesterol.pdf