2024-03-19T02:25:13Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1513362017-07-05T12:17:13Zcom_10261_9676com_10261_8col_10261_9677
DIGITAL.CSIC
author
Castillo, Vanessa
author
Lázaro, J. Tomás
author
Sardanyés, Josep
funder
European Commission
funder
Ministerio de Ciencia e Innovación (España)
funder
Generalitat de Catalunya
funder
Lobachevsky University
funder
Fundación Botín
2017-06-13T09:07:01Z
2017-06-13T09:07:01Z
2017-03
Computational and Applied Mathematics 36(1): 415–431 (2017)
0101-8205
http://hdl.handle.net/10261/151336
10.1007/s40314-015-0234-3
1807-0302
http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100004837http://dx.doi.org/10.13039/501100002809http://dx.doi.org/10.13039/501100006373
Cancer is a complex disease and thus is complicated to model. However, simple models that describe the main processes involved in tumoral dynamics, e.g., competition and mutation, can give us clues about cancer behavior, at least qualitatively, also allowing us to make predictions. Here, we analyze a simplified quasispecies mathematical model given by differential equations describing the time behavior of tumor cell populations with different levels of genomic instability. We find the equilibrium points, also characterizing their stability and bifurcations focusing on replication and mutation rates. We identify a transcritical bifurcation at increasing mutation rates of the tumor cells. Such a bifurcation involves a scenario with dominance of healthy cells and impairment of tumor populations. Finally, we characterize the transient times for this scenario, showing that a slight increase beyond the critical mutation rate may be enough to have a fast response towards the desired state (i.e., low tumor populations) by applying directed mutagenic therapies.
eng
closedAccess
Applied mathematics
Bifurcations
Cancer
Complex systems
Quasispecies dynamics
Dynamics and bifurcations in a simple quasispecies model of tumorigenesis
artículo
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URL
https://digital.csic.es/bitstream/10261/151336/1/accesoRestringido.pdf
File
MD5
42637ae8545636bc41605c1740a9a84e
15753
application/pdf
accesoRestringido.pdf