2024-03-19T12:19:01Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1429982021-11-22T12:46:01Zcom_10261_11773com_10261_1col_10261_11774
DIGITAL.CSIC
author
Carnero, Amancio
author
Blanco-Aparicio, Carmen
author
Yasaei, Hemad
funder
Japan Science and Technology Agency
funder
National Centre for the Replacement, Refinement and Reduction of Animals in Research (UK)
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
Red Temática de Investigación Cooperativa en Cáncer (España)
funder
European Commission
funder
Ministerio de Ciencia e Innovación (España)
funder
Junta de Andalucía
funder
National Institute of Environmental Health Sciences (US)
funder
Maine Center for Toxicology and Environmental Health
funder
National Institutes of Health (US)
funder
Kuwait Foundation for the Advancement of Sciences
funder
Ministry of Education, Culture, Sports, Science and Technology (Japan)
funder
Department of Science and Technology (India)
funder
U.S. Public Health Service
funder
Università degli Studi di Firenze
funder
Ministry of Education (Malaysia)
funder
Ministero dell'Istruzione, dell'Università e della Ricerca
2017-01-25T12:27:33Z
2017-01-25T12:27:33Z
2015-06-19
Carcinogenesis 36(Suppl 1): S19-S37 (2015)
http://hdl.handle.net/10261/142998
10.1093/carcin/bgv029
http://dx.doi.org/10.13039/501100002241http://dx.doi.org/10.13039/501100000849http://dx.doi.org/10.13039/501100004587http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100004837http://dx.doi.org/10.13039/100000066http://dx.doi.org/10.13039/100000002http://dx.doi.org/10.13039/501100003286http://dx.doi.org/10.13039/501100001700http://dx.doi.org/10.13039/100007197http://dx.doi.org/10.13039/501100004434http://dx.doi.org/10.13039/501100003407http://dx.doi.org/10.13039/501100001409http://dx.doi.org/10.13039/501100011011
26106138
© The Author 2015. Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells that acquire a growth advantage over the remaining cell population through the acquisition of 'driver mutations' enabling a selective advantage in a particular micro-environment. Clonal selection is the driving force behind tumorigenesis and possesses three basic requirements: (i) effective competitive proliferation of the variant clone when compared with its neighboring cells, (ii) acquisition of an indefinite capacity for self-renewal, and (iii) establishment of sufficiently high levels of genetic and epigenetic variability to permit the emergence of rare variants. However, several questions regarding the process of clonal evolution remain. Which cellular processes initiate carcinogenesis in the first place? To what extent are environmental carcinogens responsible for the initiation of clonal evolution? What are the roles of genotoxic and non-genotoxic carcinogens in carcinogenesis?
eng
closedAccess
Mutation
Tumorigenesis
Elderly
Carcinogenesis
Cell aging
Carcinogens
Aging
Disruptive chemicals, senescence and immortality
artículo
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URL
https://digital.csic.es/bitstream/10261/142998/1/accesoRestringido.pdf
File
MD5
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application/pdf
accesoRestringido.pdf