2024-03-28T15:48:04Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1426762021-12-28T16:08:46Zcom_10261_125com_10261_2col_10261_378
DIGITAL.CSIC
author
Salazar, Nuria
author
Gueimonde Fernández, Miguel
author
González de los Reyes-Gavilán, Clara
author
Ruas-Madiedo, Patricia
funder
Ministerio de Economía y Competitividad (España)
funder
European Commission
2017-01-18T10:56:29Z
2017-01-18T10:56:29Z
2014-05-29
BioMed Research International 2014: 106290 (2014)
http://hdl.handle.net/10261/142676
10.1155/2014/106290
http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/501100000780
24971309
Fermented dairy products are the usual carriers for the delivery of probiotics to humans, Bifidobacterium and Lactobacillus being the most frequently used bacteria. In this work, the strains Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 were tested for their capability to modulate immune response and the insulin-dependent glucose homeostasis using male Wistar rats fed with a standard diet. Three intervention groups were fed daily for 24 days with 10% skimmed milk, or with 109 cfu of the corresponding strain suspended in the same vehicle. A significant increase of the suppressor-regulatory TGF-β cytokine occurred with both strains in comparison with a control (no intervention) group of rats; the highest levels were reached in rats fed IPLA R1. This strain presented an immune protective profile, as it was able to reduce the production of the proinflammatory IL-6. Moreover, phosphorylated Akt kinase decreased in gastroctemius muscle of rats fed the strain IPLA R1, without affecting the glucose, insulin, and HOMA index in blood, or levels of Glut-4 located in the membrane of muscle and adipose tissue cells. Therefore, the strain B. animalis subsp. lactis IPLA R1 is a probiotic candidate to be tested in mild grade inflammation animal models. © 2014 Nuria Salazar et al.
eng
openAccess
Immune modulating capability of two exopolysaccharide-producing bifidobacterium strains in a wistar rat model
artículo
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URL
https://digital.csic.es/bitstream/10261/142676/1/Immune%20Modulating-Salazar.pdf
File
MD5
fdd9ac0f03331f2a2d0ba191fdabff85
1902277
application/pdf
Immune Modulating-Salazar.pdf