2024-03-28T20:37:29Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1237232016-06-23T10:52:04Zcom_10261_103com_10261_1col_10261_356
DIGITAL.CSIC
author
García-Robles, Inmaculada
author
Peña, Marcos de la
funder
Ministerio de Educación y Ciencia (España)
funder
Generalitat Valenciana
2015-10-22T10:15:07Z
2015-10-22T10:15:07Z
2010-08-12
RNA
1355-8382
http://hdl.handle.net/10261/123723
http://dx.doi.org/10.13039/501100003359
Examples of small self-cleaving RNAs embedded in noncoding regions already have been found to be involved in the control of gene expression, although their origin remains uncertain. In this work, we show the widespread occurrence of the hammerhead ribozyme (HHR) motif among genomes from the Bacteria, Chromalveolata, Plantae, and Metazoa kingdoms. Intergenic HHRs were detected in three different bacterial genomes, whereas metagenomic data from Galapagos Islands showed the occurrence of similar ribozymes that could be regarded as direct relics from the RNA world. Among eukaryotes, HHRs were detected in the genomes of three water molds as well as 20 plant species, ranging from unicellular algae to vascular plants. These HHRs were very similar to those previously described in small RNA plant pathogens and, in some cases, appeared as close tandem repetitions. A parallel situation of tandemly repeated HHR motifs was also detected in the genomes of lower metazoans from cnidarians to invertebrates, with special emphasis among hematophagous and parasitic organisms. Altogether, these findings unveil the HHR as a widespread motif in DNA genomes, which would be involved in new forms of retrotransposable elements.
eng
openAccess
RNA world, satellite DNA, viroid, three-helical junction
Ubiquitous presence of the hammerhead ribozyme motif along the tree of life.
artículo
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URL
https://digital.csic.es/bitstream/10261/123723/1/RNA-2010-de%20la%20Pe%c3%b1a-1943-50.pdf
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RNA-2010-de la Peña-1943-50.pdf.txt
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https://digital.csic.es/bitstream/10261/123723/7/RNA-2010-de%20la%20Pe%c3%b1a-1943-50.pdf.txt
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RNA-2010-de la Peña-1943-50.pdf.txt