2024-03-19T10:29:39Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1021152021-06-11T07:45:33Zcom_10261_115com_10261_3col_10261_368
DIGITAL.CSIC
author
Sánchez-Sánchez, Ana
author
Akbari, Somayeh
author
Etxeberria, Agustín
author
Arbe, Arantxa
author
Gasser, Urs
author
Moreno Segurado, Ángel J.
author
Colmenero de León, Juan
author
Pomposo, José A.
funder
European Commission
funder
Ministerio de Economía y Competitividad (España)
funder
Eusko Jaurlaritza
2014-09-15T13:07:37Z
2014-09-15T13:07:37Z
2013
ACS Macro Letters 2(6): 491-495 (2013)
http://hdl.handle.net/10261/102115
10.1021/mz400173c
http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/501100003086
We report herein a very efficient synthesis strategy for the construction of artificial transient-binding protein-mimic nano-objects. Michael addition-mediated multidirectional self-assembly of individual polymeric chains at r.t. leads to >Michael> nanocarriers that in solution resemble disordered multidomain proteins, as revealed by a combination of small angle neutron scattering measurements and coarse-grained molecular dynamics simulation results, whereas in the dry state adopt a collapsed, globular morphology, as observed by transmission electron microscopy. This extended-to-compact morphology transition taking place upon solvent removal is of paramount importance, among other applications, for the construction of efficient biosensors based on immobilized protein-mimic nano-objects and for the development of transient vitamin-binding systems. As a proof of concept, we show the controlled delivery of vitamin B9 from these novel transient-binding nanocarriers. © 2013 American Chemical Society.
eng
openAccess
"Michael" nanocarriers mimicking transient-binding disordered proteins
artículo
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URL
https://digital.csic.es/bitstream/10261/102115/4/Michael%20nanocarriers.pdf
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Michael nanocarriers.pdf.txt
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Michael nanocarriers.pdf.txt