2024-03-28T20:45:00Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1016372021-12-28T16:48:09Zcom_10261_13com_10261_8col_10261_266
DIGITAL.CSIC
author
Ramírez, Óscar
author
Olalde, Iñigo
author
Lorente-Galdós, Belén
author
Lalueza-Fox, Carles
author
Marqués-Bonet, Tomàs
funder
European Commission
funder
Eusko Jaurlaritza
funder
Ministerio de Ciencia e Innovación (España)
funder
Junta de Andalucía
2014-09-04T08:34:06Z
2014-09-04T08:34:06Z
2014-06-12
BMC Genomics 15: 465 (2014)
1471-2164
http://hdl.handle.net/10261/101637
10.1186/1471-2164-15-465
http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100004837http://dx.doi.org/10.13039/501100003086http://dx.doi.org/10.13039/501100011011
24923435
[Background] Although a variety of genetic changes have been implicated in causing phenotypic differences among dogs, the role of copy number variants (CNVs) and their impact on phenotypic variation is still poorly understood. Further, very limited knowledge exists on structural variation in the gray wolf, the ancestor of the dog, or other closely related wild canids. Documenting CNVs variation in wild canids is essential to identify ancestral states and variation that may have appeared after domestication.
[Results] In this work, we genotyped 1,611 dog CNVs in 23 wolf-like canids (4 purebred dogs, one dingo, 15 gray wolves, one red wolf, one coyote and one golden jackal) to identify CNVs that may have arisen after domestication. We have found an increase in GC-rich regions close to the breakpoints and around 1 kb away from them suggesting that some common motifs might be associated with the formation of CNVs. Among the CNV regions that showed the largest differentiation between dogs and wild canids we found 12 genes, nine of which are related to two known functions associated with dog domestication; growth (PDE4D, CRTC3 and NEB) and neurological function (PDE4D, EML5, ZNF500, SLC6A11, ELAVL2, RGS7 and CTSB).
[Conclusions] Our results provide insight into the evolution of structural variation in canines, where recombination is not regulated by PRDM9 due to the inactivation of this gene. We also identified genes within the most differentiated CNV regions between dogs and wolves, which could reflect selection during the domestication process.
eng
openAccess
Domestication
CNV
Candidate genes
Dog and wolf
Analysis of structural diversity in wolf-like canids reveals post-domestication variants
artículo
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URL
https://digital.csic.es/bitstream/10261/101637/1/carles.pdf
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https://digital.csic.es/bitstream/10261/101637/5/carles.pdf.txt
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carles.pdf.txt