2024-03-28T11:45:37Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/960362017-05-24T13:44:30Zcom_10261_42343com_10261_2col_10261_42344
00925njm 22002777a 4500
dc
Santa Olalla, L. M. de
author
Sánchez-Muniz, F. J.
author
Vaquero, M. Pilar
author
2009
Polyunsaturated fatty acids (PUFA) of the n-3 series are essential for normal growth and development. The health effects of these fatty acids include reduction of cardiovascular risk due to antiarrhythmic, antiinflammatory, anti-thrombotic and lipid lowering actions. An increase in unsaturation of the muscle membrane fatty acids is associated with improved insulin sensitivity. Higher proportion of n-3 fatty acids may have beneficial roles, such as antiobesity effects and protection against the metabolic syndrome and type 2 diabetes mellitus through a number of metabolic effects. However, controversy exists on the different effects of n-6 and n-3 polyunsaturated fatty acids as well as on the interacting effect of dietary saturated and monounsaturated fat. In addition, some adverse effects have been described concerning the use of fish oil supplements containing high doses of n-3 fatty acids. Several studies show Eskimos diabetes risk, while results of nutritional interventions on the influence of consuming diets rich in oily fish or other food rich in n- 3 fatty acids is very limited. This article reviews the possible mechanisms through which n-3 PUFA are involved in glucose level control and insulin sensitivity. Intervention and epidemiological studies together with recent findings on the nutrigenomic field related with this subject are also briefly reviewed.
Nutricion Hospitalaria 24: 113- 127 (2009)
http://hdl.handle.net/10261/96036
Diabetes mellitus tipo 2
Resistencia a la insulina
Aceite de pescado
Ácidos grasos n-3
Nutrigenómica
Revisión N-3 fatty acids in glucose metabolism and insulin sensitivity