2024-03-29T07:24:06Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/878752019-03-18T15:14:45Zcom_10261_41com_10261_1col_10261_294
00925njm 22002777a 4500
dc
Estarás, Conchi
author
Akizu, Naiara
author
García, Alejandra
author
Beltrán, Sergi
author
Cruz, Xavier de la
author
Martínez-Balbás, Marian
author
2012
Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFβ developmental program to proceed.
Development 139(15): 2681-2691 (2012)
http://hdl.handle.net/10261/87875
10.1242/dev.078345
http://dx.doi.org/10.13039/100008666
http://dx.doi.org/10.13039/501100003339
Epigenetic regulation
JMJD3 (Kdm6b)
Smad3
TGFβ pathway
Neurogenesis
Histone demethylation
Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program