2024-03-29T09:34:05Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/434072018-09-27T06:47:16Zcom_10261_33com_10261_5col_10261_286
00925njm 22002777a 4500
dc
Frutos, Mercedes de
author
Díez-Masa, José Carlos
author
Cifuentes, Alejandro
author
2003
Different profiles were obtained by capillary zone electrophoresis (CZE) of human ery-
thropoietin (EPO) of recombinant and urinary origin. To unambiguously detect doping
by EPO, direct methods able to determine the presence of the drug itself in a physio-
logical fluid are required. Since the host cell line used for EPO production influences its
glycosylation, the carbohydrate distribution of natural human EPO may be different
from that of recombinant EPO. The different content in sialic acid groups between
recombinant and endogenous EPO provide a basis for their distinction by CZE.
Electrophoresis 24 : 678–680 (2003)
0173-0835
http://hdl.handle.net/10261/43407
10.1002/elps.200390080
Capillary zone electrophoresis
Doping
Erythropoietin
Glycoprotein
Differences in capillary electrophoresis profiles of urinary and recombinant erythropoietin