2024-03-28T19:51:41Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/425012018-10-03T07:52:33Zcom_10261_9676com_10261_8col_10261_9677
00925njm 22002777a 4500
dc
Bortolin, Francesca
author
Piulachs, Maria-Dolors
author
Congiu, Leonardo
author
Fusco, Giuseppe
author
2011-08-19
In arthropods, molting events are mediated by the binding of the ecdysone hormone to a heterodimer of two nuclear receptors: the ecdysone receptor (EcR) and the retinoid X receptor (RXR), a homolog of ultraspiracle (USP). We have cloned partial sequences of several isoforms for EcR and RXR genes from the centipede Lithobius peregrinus, and studied their expression profile during the second post-embryonic stage. LpEcR and LpRXR inferred amino acid sequences are very similar to other arthropod orthologs, especially to those of chelicerates and hemimetabolous insects, and their expression levels are significantly higher during the 48 h that precede the molt. Results obtained in this study represent the first data on the genetic basis of the ecdysone signal pathway for a myriapod, and in particular for an animal that, through a stereotyped developmental schedule paced by the molt cycle, completes trunk segmentation during post-embryonic life.
General and Comparative Endocrinology 174 (1) : 60-69 (2011)
0016-6480
http://hdl.handle.net/10261/42501
10.1016/j.ygcen.2011.08.008
1095-6840
EcR
RXR
Molting
Myriapoda
Gene expression
Cloning and expression pattern of the ecdysone receptor and retinoid X receptor from the centipede Lithobius peregrinus (Chilopoda, Lithobiomorpha)