2024-03-28T20:22:38Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2451402021-07-03T02:41:48Zcom_10261_2288com_10261_9com_10261_41com_10261_1col_10261_204074col_10261_294
00925njm 22002777a 4500
dc
Toscano-Guerra, Emily
author
Martínez-Gallo, Mónica
author
Arrese-Muñoz, Iria
author
Gine, Anna
author
Diaz, Noelia
author
Gabriel-Medina, Pablo
author
Riveiro-Barciela, Mar
author
Labrador-Horrillo, Moisés
author
Martínez-Valle, Fernando
author
Hernández-González, Manuel
author
Rodríguez-Frías, Francisco
author
Pujol Borrell, Ricardo
author
Ferrer, Roser
author
Thomson, Timothy M.
author
Paciucci, Rosana
author
2021-07-01
Infection with SARS-CoV-2 portends a broad range of outcomes, from a majority of asymptomatic cases or mild clinical courses to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty and co-morbidities such as obesity, diabetes or cardiovascular disease. A precise knowledge is still lacking of the molecular and biological mechanisms that may explain the association of severe disease with male sex. Here, we show that testosterone trajectories are highly accurate individual predictors (AUC of ROC = 0.928, p < 0.0001) of survival in male COVID-19 patients. Longitudinal determinations of blood levels of luteinizing hormone (LH) and androstenedione suggest an early modest inhibition of the central LH-androgen biosynthesis axis in a majority of patients, followed by either full recovery in survivors or a peripheral failure in lethal cases. Moreover, failure to reinstate physiological testosterone levels was associated with evidence of impaired T helper differentiation and decrease of non-classical monocytes. The strong association of recovery or failure to reinstate testosterone levels with survival or death from COVID-19 in male patients is suggestive of a significant role of testosterone status in the immune responses to COVID-19.
MedRxiv: 10.1101/2021.06.29.21259693 (2021)
http://hdl.handle.net/10261/245140
10.1101/2021.06.29.21259693
http://dx.doi.org/10.13039/501100002809
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100003339
COVID-19
Survival
Longitudinal
Testosterone
Immune phenotype
Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients