2024-03-28T17:45:04Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2280622023-01-16T13:29:28Zcom_10261_64com_10261_1col_10261_317
00925njm 22002777a 4500
dc
Prieto-Peña, Diana
author
Remuzgo-Martínez, Sara
author
Ocejo-Vinyals, J. Gonzalo
author
Atienza-Mateo, B.
author
Muñoz-Jiménez, Alejandro
author
Ortiz-Sanjuán, Francisco
author
Romero-Yuste, Susana
author
Moriano, Clara
author
Galíndez-Agirregoikoa, E.
author
Miranda-Filloy, J. A.
author
Blanco, R.
author
Gualillo, Oreste
author
Martín, J.
author
Castañeda, Santos
author
López-Mejías, Raquel
author
González-Gay, M. A.
author
2020
Objective:To determine whether giant cell arteritis (GCA) patients with the typical pattern of cranial ischemicmanifestations and those with the extracranial large-vessel-vasculitis (LVV)-GCA phenotype exhibit differentHLA-DRB1association.Methods:178 biopsy-proven GCA patients who had cranial ischemic features but no LVV manifestations, 100patients with LVV-GCA without cranial ischemic manifestations and 486 ethnically matched healthy controlswere recruited. All patients and controls were Spanish of European ancestry. We comparedHLA-DRB1pheno-type frequencies between the three groups.Results:Both GCA subgroups had well-differentiated clinical features. Patients with LVV-GCA were younger(68.0§10.0 yearsversus74.0§10.4 years;p<0.01) and presented more commonly with polymyalgia rheu-matica symptoms (81%versus39.3%;p<0.01) than those with the classic cranial GCA phenotype.HLA-DRB1*04phenotype frequency was significantly increased in patients with classic cranial GCA compared tocontrols (42.1%versus23.5%, respectively;p<0.01; odds ratio-OR [95% confidence interval-CI] = 2.38[1.623.47]). This association was mainly due to theHLA-DRB1*04:01allele (20.8%versus5.3%, respectively;p<0.01; OR [95% CI] = 4.64 [2.638.26]).HLA-DRB1*04association was also observed in LVV-GCA patientswhen compared to controls (46.0%versus23.5%, respectively;p<0.01; OR [95% CI] = 2.78 [1.734.44]).
Seminars in Arthritis and Rheumatism 50: 897- 901 (2020)
http://hdl.handle.net/10261/228062
10.1016/j.semarthrit.2020.07.004
Giant cell arteritis
Large vessel vasculitis
HLA, Genetics
Cranial and extracranial giant cell arteritis share similar HLA-DRB1 association