2024-03-29T06:25:46Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2046952020-03-21T02:10:29Zcom_10261_25com_10261_1com_10261_2288com_10261_9col_10261_404col_10261_204074
00925njm 22002777a 4500
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Enjuanes Sánchez, Luis
author
2016-09-27
The identification of the genes involved in coronavirus (CoV) virulence and in signaling pathways contributing to pathogenesis has been addressed using SARS- and MERS-CoVs. SARS-CoV non-essential genes have been deleted using a reverse genetics system. Among them, deletion of E gene led to an attenuated phenotype (SARS-CoV-¿E), which is a vaccine candidate. The expression of proinflammatory cytokines was reduced in lungs of mice infected with a mouse adapted SARS-CoV-MA15-¿E compared to lungs infected with the wild type virus. In infections by SARS-CoV with and without E protein, NF-¿B was the only proinflammatory pathway differentially activated. Addition of an inhibitor of NF-¿B led to a reduced inflammatory response after SARS-CoV infection and to an increase in mice survival. Therefore, these inhibitors could serve as antivirals.
10th Annual Meeting EPIZONE (2016)
http://hdl.handle.net/10261/204695
Coronavirus epidemics