2024-03-28T10:18:14Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1952122019-11-24T02:12:49Zcom_10261_90com_10261_4col_10261_973
00925njm 22002777a 4500
dc
Martínez-Gómez, C.
author
Olmo, Alberto
author
Huertas, Gloria
author
Pérez, Pablo
author
Maldonado-Jacobi, A.
author
Yúfera, A.
author
2017
This work proposes a method for the study and real-time monitoring of a single cell on a 2D electrode matrix, of great interest in cell motility assays and in the characterization of cancer cell metastasis. A CMOS system proposal for cell location based on occupation maps data generated from Electrical Cell-substrate Impedance Spectroscopy (ECIS) has been developed. From experimental assays data, an algorithm based on the analysis of the eight nearest neighbours has been implemented to find the cell center of mass. The path followed by a cell, proposing a Brownian route, has been simulated with the proposed algorithm. The presented results give an accuracy over 95% in the determination of the coordinates (x, y) from the expected cell center of mass.
39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (2017)
978-1-5090-2810-8
1557-170X
http://hdl.handle.net/10261/195212
10.1109/EMBC.2017.8036954
1558-4615
Electrodes
Cancer
Two dimensional displays
Real-time systems
Fluorescence
Indexes
Sensors
A tracking algorithm for cell motility assays in CMOS systems