2024-03-29T01:02:49Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1842882023-01-12T12:46:58Zcom_10261_25com_10261_1com_10261_89com_10261_3col_10261_278col_10261_342
00925njm 22002777a 4500
dc
Conde-Leboran, Ivan
author
Baldomir, Daniel
author
MartÃnez Boubeta, Carlos
author
Chubykalo-Fesenko, O.
author
Morales, M. P.
author
Salas, Gorka
author
Cabrera, David
author
Camarero, Julio
author
Teran, Francisco José
author
Serantes, David
author
2015-07-09
Progress in the design of nanoscale magnets for localized hyperthermia cancer therapy has been largely driven by trial-and-error approaches, for instance, by changing of the stoichiometry composition, size, and shape of the magnetic entities. So far, widely different and often conflicting heat dissipation results have been reported, particularly as a function of the nanoparticle concentration. Thus, achieving hyperthermia-efficient magnetic ferrofluids remains an outstanding challenge. Here we demonstrate that diverging heat-dissipation patterns found in the literature can be actually described by a single picture accounting for both the intrinsic magnetic features of the particles (anisotropy, magnetization) and experimental conditions (concentration, magnetic field). Importantly, this general magnetic-hyperthermia scenario also predicts a novel non-monotonic concentration dependence with optimum heating features, which we experimentally confirmed in iron oxide nanoparticle ferrofluids by fine-tuning the particle size. Overall, our approach implies a magnetic hyperthermia trilemma that may constitute a simple strategy for development of magnetic nanomaterials for optimal hyperthermia efficiency.
Journal of Physical Chemistry C 119(27): 15698-15706 (2015)
http://hdl.handle.net/10261/184288
10.1021/acs.jpcc.5b02555
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100010801
A single picture explains diversity of hyperthermia response of magnetic nanoparticles