2024-03-29T13:33:24Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1821992021-10-27T10:14:48Zcom_10261_31com_10261_3com_10261_34com_10261_5col_10261_284col_10261_287
00925njm 22002777a 4500
dc
Lancelot, Alexandre
author
Claveria-Gimeno, Rafael
author
Claveria-Gimeno, Rafael
author
Abian, Olga
author
Serrano, José Luis
author
Sierra, Teresa
author
2017
The self-assembly in water of amphiphilic Janus dendrimers leads to micelles suitable to encapsulate camptothecin and act as therapy against the hepatitis C virus, HCV. Dendrimers consist of bis-MPA dendrons linked by their focal point through a CuAAC reaction. The hydrophilic dendron wears ammonium groups in its periphery whereas the lipophilic dendrons contain stearic acid chains. The morphology of the aggregates is controlled through the chemical structure of the dendrimers, particularly their molecular weight and the adequate combination of the lipophilic and hydrophilic blocks. Camptothecin-loaded dendrimer aggregates constitute effective systems to inhibit HCV replication and show low toxicity working at low drug concentrations.
European Polymer Journal 90: 136-149 (2017)
0014-3057
http://hdl.handle.net/10261/182199
10.1016/j.eurpolymj.2017.03.012
1873-1945
http://dx.doi.org/10.13039/501100007041
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100003176
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100000780
Dendrimers
Self-assembly
Micelles
Drug carriers
Camptothecin
Hepatitis C virus
Nanostructures based on ammonium-terminated amphiphilic Janus dendrimers as camptothecin carriers with antiviral activity