2024-03-29T07:39:21Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1720002019-09-09T12:18:27Zcom_10261_38com_10261_5col_10261_291
00925njm 22002777a 4500
dc
González-Ravina, Cristina
author
Aguirre-Lipperheide, Mercedes
author
Pinto Pérez, Francisco M.
author
Martín-Lozano, David
author
Fernández-Sánchez, Manuel
author
Blasco, Víctor
author
Santamaría-López, Esther
author
Candenas, M. Luz
author
2018-06
The aim of this study was to evaluate the possible beneficial effects of diet supplementation with a highly concentrated and purified docosahexaenoic acid (DHA) formula on human sperm function. We performed a prospective, randomized, double blind, placebo-controlled intervention study. One-hundred eighty human semen samples from sixty infertile patients recruited in a private assisted reproduction center were included. All samples were examined according to World Health Organization guidelines. We analyzed macroscopic and microscopic sperm parameters, oxidative stress, apoptosis, lipid peroxidation, mitochondrial membrane potential and DNA fragmentation before and after supplementation with different DHA daily doses (0.5, 1 and 2 g) or placebo for 1 and 3 months. No differences were found in traditional sperm parameters except for progressive sperm motility, with a significant increase after DHA ingestion after the first month with 1 or 2 g doses and after 3 months with 0.5 g of DHA. This effect was more evident in asthenozoospermic patients. No differences were found in any molecular semen parameter except oxidative stress, in which a slight benefit was observed after DHA treatment. In conclusion, this study support previous indications that highlight the importance of DHA supplementation as a means of improving sperm quality in asthenozoospermic men.
Reproductive Biology, 18(3): 282-288 (2018)
http://hdl.handle.net/10261/172000
10.1016/j.repbio.2018.06.002
Sperm
DNA
Oxidative stress
Spermatozoa
DHA
Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic acid (DHA) supplement on human sperm function