2024-03-29T02:03:22Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1674262021-12-28T15:48:02Zcom_10261_64com_10261_1col_10261_317
00925njm 22002777a 4500
dc
Ponte-Sucre, Alicia
author
Gamarro, Francisco
author
Dujardin, J. C.
author
Barrett, Michael P.
author
López-Vélez, Rogelio
author
García-Hernández, Raquel
author
Pountain, Andrew W.
author
Mwenechanya, Roy
author
Papadopoulou, Barbara
author
2017-12-14
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including the global HIV/AIDS epidemic with its accompanying impact on the immune system. Pentavalent antimonials have been used successfully worldwide for the treatment of leishmaniasis since the first half of the 20th century, but the last 10 to 20 years have witnessed an increase in clinical resistance, e.g., in North Bihar in India. In this review, we discuss the meaning of “resistance” related to leishmaniasis and discuss its molecular epidemiology, particularly for Leishmania donovani that causes visceral leishmaniasis. We also discuss how resistance can affect drug combination therapies. Molecular mechanisms known to contribute to resistance to antimonials, amphotericin B, and miltefosine are also outlined.
PLoS Neglected Tropical Diseases
1935-2727
http://hdl.handle.net/10261/167426
10.1371/journal.pntd.0006052
1935-2735
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/100004440
http://dx.doi.org/10.13039/501100000024
http://dx.doi.org/10.13039/100005156
http://dx.doi.org/10.13039/501100011011
29240765
AMPHOTERICIN-B RESISTANCE
PROTOZOAN PARASITE LEISHMANIA
ABC-TRANSPORTER MRPA
VISCERAL LEISHMANIASIS
DONOVANI PROMASTIGOTES
Cutaneous leishmaniasis
MILTEFOSINE RESISTANCE
Antimony-resistant
MEGLUMINE ANTIMONIATE
SODIUM STIBOGLUCONATE
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge