2024-03-28T15:35:12Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1660292021-12-28T15:40:41Zcom_10261_33com_10261_5col_10261_286
00925njm 22002777a 4500
dc
Zárate, Sandra G.
author
De La Cruz Claure, M. L.
author
Benito-Arenas, Raúl
author
Revuelta, Julia
author
Santana, Andrés G.
author
Bastida, Agatha
author
2018
Resistance to aminoglycoside antibiotics has had a profound impact on clinical practice. Despite their powerful bactericidal activity, aminoglycosides were one of the first groups of antibiotics to meet the challenge of resistance. The most prevalent source of clinically relevant resistance against these therapeutics is conferred by the enzymatic modification of the antibiotic. Therefore, a deeper knowledge of the aminoglycoside-modifying enzymes and their interactions with the antibiotics and solvent is of paramount importance in order to facilitate the design of more effective and potent inhibitors and/or novel semisynthetic aminoglycosides that are not susceptible to modifying enzymes.
Molecules 23 (2018)
http://hdl.handle.net/10261/166029
10.3390/molecules23020284
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100010198
29385736
Antibiotic resistance
Combination therapy
Decoy acceptors
Bi-substrate inhibitors
Overcoming aminoglycoside enzymatic resistance: Design of novel antibiotics and inhibitors