2024-03-28T08:56:49Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1635722021-12-28T15:52:42Zcom_10261_109com_10261_1col_10261_362
00925njm 22002777a 4500
dc
Novais Bastos, Helder
author
Osório, Nuno S.
author
Gagneux, Sebastien
author
Comas, Iñaki
author
Saraiva, Margarida
author
2018-01-09
The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.
Frontiers in Immunology 8:1948 (2018)
http://hdl.handle.net/10261/163572
10.3389/fimmu.2017.01948
1664-3224
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000781
http://dx.doi.org/10.13039/501100003359
29375571
Genotypic diversity
Immune phenotypes
Inflammation; microenvironments
Severity of disease
Tuberculosis
The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes