2024-03-28T16:17:42Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1489362020-07-31T10:31:11Zcom_10261_46com_10261_3col_10261_299
00925njm 22002777a 4500
dc
Muñoz Gómez, José L
author
Monteagudo, Eva
author
Lloveras, Vega
author
Parella, Teodor
author
Veciana, Jaume
author
Vidal Gancedo, José
author
2016-02-22
The synthesis of two novel BDPA-like radicals, a benzyl amino (BAm-BDPA, 7) and a cyano (CN-BDPA, 5)
derivative, is reported and their behaviour as polarizing agents for fast dissolution Dynamic Nuclear
Polarization (DNP) is evaluated. The radical 7 is a promising candidate for DNP studies since it is soluble
in neat [1-13C]pyruvic acid (PA), and therefore the use of an additional glassing agent for sample
homogeneity is avoided. In addition, a 60 mM sample of 7 offers optimum 13C NMR signal
enhancements using fairly short polarization times (about 1800 s). It is shown that DNP-NMR
measurements using 7 can be performed much more efficiently in terms of the signal enhancement per
polarization build-up time unit than when using the reference OX63 or BDPA radicals. These enhanced
features are translated to a substantial reduction of polarization times that represents an optimum
temporary use of the DNP polarizer and allow economized liquid helium consumption.
RSC Advances 6(32): 27077-27082 (2016)
2046-2069
http://hdl.handle.net/10261/148936
10.1039/C6RA00635C
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100002809
http://dx.doi.org/10.13039/501100005053
http://dx.doi.org/10.13039/501100008737
Dynamic nuclear-polarization
Magnetic-resonance
Enhanced NMR
Spectroscopy
Optimized polarization build-up times in dissolution DNP-NMR using a benzyl amino derivative of BDPA