2024-03-29T02:38:50Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1431712021-12-27T16:47:12Zcom_10261_11773com_10261_1col_10261_11774
00925njm 22002777a 4500
dc
Tadeo, Irene
author
Berbegall, Ana P.
author
Escudero, Luis M.
author
Álvaro, Tomás
author
Noguera, Rosa
author
2014-03-04
Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in physiological processes such as mechanotransduction and mechanosensing at different scales (from cell sensing through integrins to molecular mechanical interventions or even localized massage). The process involves intra- and extracellular components, including the participation of extracellular matrix (ECM) and microtubules that act as compression structures, and actin filaments which act as tension structures. The nucleus itself has its own tensegrity system which is implicated in cell proliferation, differentiation, and apoptosis. Despite present advances, only the tip of the iceberg has so far been uncovered regarding the role of ECM compounds in influencing biotensegrity in pathological processes. Groups of cells, together with the surrounding ground substance, are subject to different and specific forces that certainly influence biological processes. In this paper, we review the current knowledge on the role of ECM elements in determining biotensegrity in malignant processes and describe their implication in therapeutic response, resistance to chemo- and radiotherapy, and subsequent tumor progression. Original data based on the study of neuroblastic tumors will be provided. © 2014 Tadeo, Berbegall, Escudero, Álvaro and Noguera.
Frontiers in Oncology 4: article 39 (2014)
http://hdl.handle.net/10261/143171
10.3389/fonc.2014.00039
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100000780
24624363
Biotensegrity
Cancer
Neuroblastoma
Mechanotherapy
Extracellular matrix
Biotensegrity of the extracellular matrix: Physiology, dynamic mechanical balance, and implications in oncology and mechanotherapy