2024-03-29T15:26:21Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1414712016-12-20T11:04:07Zcom_10261_125com_10261_2col_10261_504
00925njm 22002777a 4500
dc
Milani, Christian
author
Margolles Barros, Abelardo
author
Ventura, Marco
author
2014-08-31
Bifidobacteria have been identified in the gut environment of a diverse set of animals, including those of mammals and insects. However, the genetic traits facilitating their adaptation to this highly competitive and variable ecological niche are still poorly characterized. Here, the genomic decoding of 47 representative (sub)species across the Bifidobacterium genus revealed a wide variety of genes predicted to be required for the breakdown and internalization of a range of carbohydrates. Such glycan-degrading abilities are expected to be a reflection of the carbon sources present in the ecological niche of bifidobacteria. Furthermore, transcriptome profiling of bifidobacterial genomes supported the involvement of various chromosomal loci in glycan metabolism. The widespread occurrence of bifidobacterial saccharolytic features was confirmed by interrogating metagenomic datasets, thereby supporting the notion that metabolic accessibility to dietary and/or host derived glycans is a potent evolutionary force that has shaped bifidobacterial genomes. This study also underscores the idea of saccharidic resource sharing among bifidobacteria through species-specific metabolic specialization and cross feeding.
11th Symposium on Lactic Acid Bacteria (2014)
http://hdl.handle.net/10261/141471
Genomics of the genus Bifidobacterium reveals species-specific adaptation to the glycan-rich gut environment