2024-03-28T17:04:52Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1111312019-03-22T13:16:48Zcom_10261_41com_10261_1col_10261_294
00925njm 22002777a 4500
dc
Verdaguer, Núria
author
Aymamí, Joan
author
Fernández-Forner, Dolors
author
Fita, Ignacio
author
Coll, Miquel
author
Huynh-Dinh, Tam
author
Igolen, Jean
author
Subirana, Juan A.
author
1991
We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.
Journal of Molecular Biology 221(2): 623-635 (1991)
http://hdl.handle.net/10261/111131
10.1016/0022-2836(91)80077-8
DNA structure
A-DNA
X-ray diffraction
Spermine
CpG sequence
Molecular structure of a complete turn of A-DNA