2024-03-29T11:25:30Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/80562016-02-16T03:37:58Zcom_10261_79com_10261_1col_10261_836
2008-10-28T16:01:49Z
urn:hdl:10261/8056
Función del gen lines y la fmailia odd-skipped en la integración de múltiples vías de señalización durante el desarrollo del ala de drosophila
Benítez, Elvira
Guerrero Vega, Isabel
Rodríguez Enríquez, Isabel
Drosophila
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura 29-02-2008
This thesis aim to investigate the lines function during the imaginal wing disc
development. It was found that lines mutant cells induce an aberrant responses to key signaling
pathways: Notch (N), Wingless (Wg), JAK/STAT, Decapentaplegic (Dpp) and EGFR, which
yield changes in the proximal-distal cell identity and a cell dramatic overgrowth.
A regulatory network involving Lines/Drumstick/Bowl is implicated in the integration
of patterning information at several stages during the development. It was shown that the
same cassette is important in integrating several different signaling events in the developing
wing. Moreover, two additional members of the odd-skipped family were included to this
regulatory network, odd and sob. Drm, Odd and Sob inhibit Lines functions allowing Bowl
nuclear accumulation. Drm controls nuclear Lines levels, Lines turns down the steady-state
accumulation of Bowl protein in the wing disc. Odd and Sob fail in Lines relocalization to
the cytoplasm but their ability to interact with Bowl suggests that the formation of a protein
complex would inhibit Lines function. Genetic experiments show that Bowl is the primary
effector of this regulatory network.
In this generic network Drm/Lines/Bowl, lines is implicated in the wing development
by limiting Bowl expression to the peripodial cells. A genetic interaction between Lines/Bowl
and Groucho, a general co-repressor of N, Wg, EGFR, and Dpp pathways it was found. It is
proposed that Lines is a modular factor of transcriptional complexes that integrates the response
to different signaling pathways to control patterning and growth during development.
2008-10-28T16:01:49Z
2008-10-28T16:01:49Z
2008
tesis doctoral
http://hdl.handle.net/10261/8056
spa
openAccess
Universidad Autónoma de Madrid