2024-03-28T09:29:21Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/626202021-11-22T12:44:51Zcom_10261_11773com_10261_1col_10261_11774
2012-12-12T11:12:37Z
urn:hdl:10261/62620
HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients
González-Serna, Manuel Alejandro
Romero-Sánchez, M.
Ferrando-Martínez, Sara
Genebat, Miguel
Vidal, Francesc
Muñoz-Fernández, María Ángeles
Abad Arranz, María
Leal, Manuel
Ruiz-Mateos, Ezequiel
We analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT + and MCT - patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT + patients, while X4IVLs increased only in MCT - patients, with X4IVLs of >2 log 10 HIV RNA copies/ml. These results shed light on the evolution of viral tropism under a CCR5 antagonist in vivo. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
2012-12-12T11:12:37Z
2012-12-12T11:12:37Z
2012
2012-12-12T11:12:37Z
artículo
Antimicrobial Agents and Chemotherapy 56(7): 3981-3983 (2012)
http://hdl.handle.net/10261/62620
10.1128/AAC.00507-12
22547624
eng
closedAccess
American Society for Microbiology