2024-03-28T10:55:22Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/568962016-02-17T06:15:20Zcom_10261_22com_10261_1com_10261_133col_10261_275col_10261_386
2012-09-28T09:56:49Z
urn:hdl:10261/56896
Hypothyroxinemia: A subclinical condition affecting neurodevelopment
Berbel, Pere
Bernal, Juan
Hypothyroxinemia with low levels of circulating free thyroxine and normal levels of thyrotropin, which is usually caused by iodine deficiency, may affect pregnant women even in apparently iodine-sufficient areas, and it is debated whether it increases the risk of neurodevelopmental abnormalities in children born to them. Epidemiological observations indeed indicate that this is the case. Animal models show abnormal brain cortical cytoarchitecture in pups born to mildly hypothyroxinemic dams. In regions where the availability and use of iodized salt is inadequate (where <90% of households use iodized salt), the WHO and the International Council for Control of Iodine Deficiency Disorders (ICCIDD) recommend iodine supplementation so that the total iodine intake is 250 g/day to prevent iodine deficiency during gestation and lactation. © 2010 Expert Reviews Ltd.
2012-09-28T09:56:49Z
2012-09-28T09:56:49Z
2010
2012-09-28T09:56:50Z
artículo
Expert Review of Endocrinology and Metabolism 5(4): 563- 575 (2010)
http://hdl.handle.net/10261/56896
10.1586/eem.10.37
eng
closedAccess
Future Drugs