2024-03-29T04:51:24Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/482162021-05-12T01:27:45Zcom_10261_79com_10261_1col_10261_332
2012-04-12T17:28:58Z
urn:hdl:10261/48216
Cell proliferation in the attainment of constant sizes and shapes: the Entelechia model
García-Bellido, Antonio C.
García-Bellido, Antonio
Pattern formation
Growth control
Clonal analysis
Compartment borders
The Entelechia model is a generative model of morphogenesis where individual cells
exhibit surface labels that express scalar difference and planar polarity along two orthogonal axes
X and Y. The amount of surface label depends on the level of Martial (M) gene product within each
cell. The model assumes that the confrontation of cells on both sides of compartment borders
causes an increase in their level of M gene expression. The resulting disparity between the M value
of border cells and that of their neighbors induces the latter to divide. After each division the
daughter cells increase their own M value, and allocate to the best matching value position. The
increase in M value at the borders therefore extends through the anlage in a cascade of proliferation.
The Entelechia condition is reached when the border cells attain the species-specific maximal M
values, and the value differences between adjacent cells become indistinguishable. Computer
simulations reveal that this model accounts for a variety of observations made on imaginal discs,
e.g., 1) each disc attains a constant size in terms of number of cells, independently of the growing
conditions; 2) clonal restrictions separate populations of cells which proliferate by intercalar
growth; 3) dissociated cells are capable of reconstructing original patterns upon reaggregation, and
4) genetic mosaics of morphogenetic mutations show local effects that may differ depending on the
position of the mutant cells in the growing anlage.
2012-04-12T17:28:58Z
2012-04-12T17:28:58Z
1998
artículo
International Journal of Developmental Biology 42: 353-362 (1998)
0214-6282
http://hdl.handle.net/10261/48216
eng
http://www.ijdb.ehu.es/web/paper.php?doi=9654019&a=f
closedAccess
University of British Columbia Press