2024-03-29T21:53:42Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/478262021-05-12T01:27:49Zcom_10261_79com_10261_1col_10261_332
2012-04-02T12:59:24Z
urn:hdl:10261/47826
Developmental Genetic Analysis of Contrabithorax Mutations in Drosophila Melanogaster
González-Gaitán, M. A.
Micol, J. L.
García-Bellido, Antonio
Comisión Asesora de Investigación Científica y Técnica, CAICYT (España)
Comisión Interministerial de Ciencia y Tecnología, CICYT (España)
Fundación Ramón Areces
Fundación Juan March
Instituto de Salud Carlos III
Contrabithorax
Drosophila
Melanogaster
Ultrabithorax
A developmental analysis of the Contrabithorax (Cbx) alleles offers the opportunity to examine the role of the Ultrabithorax (Ubx) gene in controlling haltere, as alternative to wing, morphogenesis in Drosophila. Several Cbx alleles are known with different spatial specificity in their wing toward haltere homeotic transformation. The molecular data on these mutations, however, does not readily explain differences among mutant phenotypes. In this work, we have analyzed the ``apogenetic'' mosaic spots of transformation in their adult phenotype, in mitotic recombination clones and in the spatial distribution of Ubx proteins in imaginal discs. The results suggest that the phenotypes emerge from early clonality in some Cbx alleles, and from cell-cell interactions leading to recruitment of cells to Ubx gene expression in others. We have found, in addition, mutual interactions between haltere and wing territories in pattern and dorsoventral symmetries, suggesting short distance influences, ``accommodation,'' during cell proliferation of the anlage. These findings are considered in an attempt to explain allele specificity in molecular and developmental terms.
2012-04-02T12:59:24Z
2012-04-02T12:59:24Z
1990
artículo
Genetics 126(1): 139–155 (1990)
0016-6731
http://hdl.handle.net/10261/47826
http://dx.doi.org/10.13039/501100007272
http://dx.doi.org/10.13039/501100007273
http://dx.doi.org/10.13039/100008054
http://dx.doi.org/10.13039/501100009154
http://dx.doi.org/10.13039/501100004587
eng
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204118/pdf/ge1261139.pdf
closedAccess
Genetics Society of America