2024-03-29T11:15:59Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/379972022-05-25T11:02:09Zcom_10261_79com_10261_1col_10261_332
2011-07-26T10:57:28Z
urn:hdl:10261/37997
Citrate inhibition of phosphofructokinase and the Pasteur effect
Salas, María Luisa
Viñuela, Eladio
Salas, Margarita
Sols, Alberto
National Institutes of Health (US)
A large amount of recent evidence clearly indicates that the
regulation of phosphofructokinase (PFK) activity is fundamental in
the control of glycolysis (Lowry and Passonneau, 1964) through a
series of feedback mechanisms (Sols et., 1963). Endproduct
inhibition of PFK by ATP (ViRuela et. , 1963) may account for
the Pasteur effect in certain tissues (Wu, 1964) . Nevertheless, it
has been reported that in glucose utilizing yeast, where both the
Pasteur effect and an involvement of PFK in it were first observ -
ed, the level of ATP is essentially the same in aerobiosis and an-
aerobiosis (1-ynen et. , 1959) . Evidence reported here indicates
that an additional feedback inhibition involving citrate may account
for the aerobic regulation of PFK activity in yeast.
2011-07-26T10:57:28Z
2011-07-26T10:57:28Z
1965
artículo
Biochemical and Biophysical Research Communications 19(3): 371-376 (1965)
0006-291X
http://hdl.handle.net/10261/37997
10.1016/0006-291X(65)90471-7
http://dx.doi.org/10.13039/100000002
eng
http://dx.doi.org/10.1016/0006-291X(65)90471-7
closedAccess
Elsevier