2024-03-29T13:27:21Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/248372022-12-15T10:51:16Zcom_10261_22com_10261_1col_10261_275
2010-05-28T11:29:06Z
urn:hdl:10261/24837
Generation and characterization of dickkopf3 mutant mice
Montero-Pedrazuela, Ana
Guadaño-Ferraz, Ana
Obregón, María Jesús
Martínez de Mena, Raquel
Morreale de Escobar, Gabriella
Bernal, Juan
Niehrs, Christof
Instituto de Salud Carlos III
German Research Foundation
10 pages, 3 figures, 7 tables.-- et al.
dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Dkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels. Mutant mice are euthyroid, and the data do not support a relationship of dkk3 with thyroid hormone metabolism. Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity.
2010-05-28T11:29:06Z
2010-05-28T11:29:06Z
2006-03
artículo
Molecular and Cellular Biology 26(6): 2317-2326 (2006)
0270-7306
http://hdl.handle.net/10261/24837
10.1128/MCB.26.6.2317-2326.2006
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100001659
16508007
eng
http://dx.doi.org/10.1128/MCB.26.6.2317-2326.2006
closedAccess
American Society for Microbiology