2024-03-28T21:00:24Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2081182020-04-18T01:08:49Zcom_10261_31com_10261_3col_10261_284
2020-04-17T12:14:17Z
urn:hdl:10261/208118
Polymeric self-assemblies based on tetra-ortho-substituted azobenzene as visible light responsive nanocarriers
Roche, Alejandro
Oriol, Luis
Tejedor, Rosa M.
Piñol, Milagros
Ministerio de Economía y Competitividad (España)
Roche, Alejandro [0000-0003-1391-3725]
Oriol, Luis [0000-0002-0922-5615]
Piñol, Milagros [0000-0001-5556-2172]
Azobenzene
Block copolymers
Self-assembly
Nanocarriers
This article belongs to the Special Issue Photoresponsive Polymeric Materials.
Most of reported polymeric light-responsive nanocarriers make use of UV light to trigger morphological changes and the subsequent release of encapsulated cargoes. Moving from UV- to visible-responsive units is interesting for the potential biomedical applications of these materials. Herein we report the synthesis by ring opening polymerization (ROP) of a series of amphiphilic diblock copolymers, into which either UV or visible responsive azobenzenes have been introduced via copper(I) catalyzed azide-alkyne cycloaddition (CuAAC). These copolymers are able to self-assemble into spherical micelles or vesicles when dispersed in water. The study of the response of the self-assemblies upon UV (365 nm) or visible (530 or 625 nm) light irradiation has been studied by Transmission Electron Microscopy (TEM), Cryogenic Transmission Electron Microscopy (Cryo-TEM), and Dynamic Light Scattering (DLS) studies. Encapsulation of Nile Red, in micelles and vesicles, and Rhodamine B, in vesicles, and its light-stimulated release has been studied by fluorescence spectroscopy and confocal microscopy. Appreciable morphological changes have been induced with green light, and the subsequent release of encapsulated cargoes upon green light irradiation has been confirmed.
2020-04-17T12:14:17Z
2020-04-17T12:14:17Z
2019
artículo
Polymers 11(12): 2060 (2019)
http://hdl.handle.net/10261/208118
10.3390/polym11122060
2073-4360
http://dx.doi.org/10.13039/501100003329
31835773
eng
Publisher's version
https://doi.org/10.3390/polym11122060
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2014-55205-P
https://creativecommons.org/licenses/by/4.0/
openAccess
Multidisciplinary Digital Publishing Institute