2024-03-29T10:40:50Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/192942016-02-16T05:58:02Zcom_10261_31com_10261_3col_10261_284
2009-12-03T09:17:28Z
urn:hdl:10261/19294
Novel gold(I) 7-azacoumarin complex: Synthesis, structure, optical properties, and cytotoxic effects
Casas, José S.
Castellano, Eduardo E.
Couce, María D.
Crespo, Olga
Ellena, Javier
Laguna, Antonio
Sánchez, Agustin
Sordo, José
Taboada, Carmen
3 pages, 2 tables, 1 scheme, 1 figure.
A mixture of pyridoxalrhodanine, triethylphosphinegold(I) chloride, and sodium methoxide in methanol unexpectedly afforded the azacoumarin complex [Au(TS)(PEt3)] [HTS = 5-(hydroxymethyl)-8-methyl-3-thiol-7-azacoumarin], which was characterized by X-ray diffractometry. Its crystals consist of independent molecules in which the metal atom is bound to the azacoumarin [Au−S = 2.9458(18) Å] and the phosphine [Au−P = 2.262(2) Å] in an almost linear arrangement [P1−Au1−S1 = 176.93(7)°]. The complex showed better in vitro antitumor activity than cisplatin against the cisplatin-resistant cell line A2780cis.
2009-12-03T09:17:28Z
2009-12-03T09:17:28Z
2007-06-30
artículo
Inorg. Chem. 46(16): 6236–6238 (2008)
http://hdl.handle.net/10261/19294
10.1021/ic700861a
eng
http://dx.doi.org/10.1021/ic700861a
closedAccess
American Chemical Society